GW 501516 (Cardarine): The Ultimate PPAR for Endurance and Fat Loss

GW 501516 (or Cardarine) is a research chemical developed in the 1990s to prevent and cure tumor formation in the colon, prostate, and breasts. Studies done in the early 2000s have found that GW 501516 and other PPAR agonists have also been able to stop metabolic disorders such as obesity and diabetes through specific gene expressions.

As research continued to grow, bodybuilders quickly caught on to GW 501516, calling it the ultimate endurance enhancing supplement. GW’s ability to burn off excess fatty tissue, enhance recovery, and dramatically increase endurance  has made this product a staple in every athlete’s cycle and PCT. With no harmful side effects found in the past 20 years, no wonder why GW 501516 has become a legend in the world of sports and athleticism.

Let’s take a closer look…

The Benefits of GW 501516

  • GW 501516 is the “ultimate endurance enhancer” – It’s used by elite athletes and competitors for a reason.
  • Gives you insane energy levels – so you can push harder in the gym, increase your intensity, and bust through plateaus like never before.
  • Decreases recovery time – meaning you can lift almost every day while taking GW.
  • Will rapidly melt fat, but is NON CATABOLIC. That means you’ll keep all your gains while getting leaner.
  • Will get you immediate, noticeable results: literally on the first dose.
  • Provides one of the cleanest energies. It’s not a stimulant, so you won’t crash or feel anxious at all.
  • The ability to run for as long as 12 weeks. You’ll get better and better results the longer you take it.
  • Is versatile – can be stacked with virtually anything.
  • Can be used while cutting or bulking. Cardarine will accelerate your results no matter what you do.
  • Gives you an overall sense of health and well being. You’ll feel amazing while you’re on it.
  • No side effects, liver toxicity, or suppression have been reported. There’s no need for  PCT either.
  • Called the possible cure for obesity, Cardarine allows you to lose weight by using fat stores for energy rather than carbohydrates.

Cardarine: The Cure for Obesity?

THE PRIMARY ROLE is GW’s ability to rid the body of unwanted fatty tissue and it has become almost LEGENDARY. The chemical compounds in this particular PPAR agonist functions in differentiation of adipocytes.

Much like growth hormone, GW 501516 generates proinflammatory markers in adipose tissue and decreasing the activity of genes involved in lipogenesis. This means that the body is able to block fatty acid chains from forming and being stored as fat.

A study from Scientific Reports published in 2015 stated

“GW501516 acts on PPAR beta cells that exclusively use body fat as energy in the same way the body would when going through “starvation mode”.

The study is quoted stating: “physiological and pathophysiological functions of PPAR and generated novel strategies to treat metabolic diseases”.

The activation of these particular genes in the body have been seen to burn body fat at such an alarming rate that it is being coined “the cure to obesity”.

There were absolutely no adverse side effects detected in the last 20 years of study and it was extremely rare to see muscle wasting at any point during the research.

Effects on Muscle Fibers

The 2015 study by Wei Chen, PhD and his colleges has also found that dramatic increases in the PPAR gene in slow twitch muscle fibers increases oxygen usage and greatly increases endurance. The enhanced endurance was seen in lab mice with a normal oxygen supply and those with oxygen restrictions which provided significant evidence that GW501516 targets and enhances skeletal muscle endurance and recovery time to a supraphysiological level.

Lab_mouse_mg_3263

A study titled “A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice” stated that BCAA were spared during trials of intense exercise which allowed the mice to have a greater rate of recovery in muscle tissue and neurotransmitters.

These rats had even lost weight while maintaining a high fat diet, suggesting it could potentially prevent obesity and help manage weight regardless of eatings habits.   

Recommendations & Dosing Guidelines for Cardarine

  • 10-20 mg per day is a sufficient dose. It is recommended to start at 10mg per day to take advantage of the host’s sensitivity to the new chemical. 10 mg a day is aimed for endurance, and the higher the dosage the greater the fat loss benefits are going to be
  • Lab mice should be given dosages 45 minutes- 1 hour before exercise.
  • GW501516 has been tested for a 2 year study and has found no decreases or stagnation in effects. Most individuals run cycles for 12-14 weeks at a time with a 4-6 week break. This is normally to coincide with a SARM cycle, but there is no evidence showing that GW 501516 needs to be off-cycled after such a short amount of time. GW501516 was created for LONG TERM usage, so there is no reason why it shouldn’t be used that way.
  • Half life is between 16-24 hours and should be take at 10mg once a day or 10mg once every 10-12 hours if taken at a higher dose.
  • No PCT is needed, GW is recommended in combination with PCT if highly toxic anabolics have been used.
  • Highly recommended to use with a ketogenic diet.
  • Can be used in conjunction with anabolics and stimulants of any kind without adverse reactions.

How GW 501516 Works

GW 501516 Cardarine
GW 501516 Cardarine Chemical Composition

GW stimulates glucose uptake and skeletal muscle tissue. It burns fat by stimulating fatty acid oxidation. It’s suggested as a potential treatment for obesity because of it’s ability to rapidly melt fat. Also, Cardarine is said to increase HDL by an average of 79% (good cholesterol) and decrease LDL (bad cholesterol) in current Phase II trials. GW 501516 is a PPARδ agonist. These help increase your HDL levels from an enhanced expression of the cholesterol transporter ABCA1.

The Side Effects of GW 501516

Not to say that there are none, but in the last 20 years no side effects have been seen by anyone studying the drug.

GW501516 has not only been tested in healthy subjects, but also those with simulated “real life” habits (such as drinking alcohol, stimulant narcotics, and the use of tobacco products). It is uncertain if there are long term ramifications, but no research has been published stating otherwise.

This is what makes Cardarine so incredibly popular and usable over long periods of time. In certain studies, there have even been signs showing the reversal of diabetes, obesity, Dyslipidemia and many other diseases.

GW 501516 & Liver Damage

In contrast to popular belief, GW501516 doesn’t promote damage of liver cells. The chemical has actually been known to promote healthy liver function and faster healing properties to the skin and muscle tissue. In essence, you will not heal rapidly like Wolverine from the X Men movies, but you will shorten the your recovery time from scratches, blisters, and injured muscles by a significant amount.

GW 501516 & Cancer

There has been many forum comments expressing the concerns of GW501516 and it’s  relationship to cancer and tumor development. The hypothesis for this controversy stems from GW’s ability to improve angiogenesis in the body at an extremely high rate and the rate of cancer growth in the colons of lab mice. Angiogenesis refers to the bodies ability to increase blood supply to feed the cells throughout the body.

This is a common occurrence among endurance athletes and children going through adolescence. Scientist had speculation that if there were tumor cells active in the body, that they would be especially susceptible to angiogenesis and cause the tumor to grow at a much faster rate. Since 2004 many experiments have been done to prove this hypothesis, but so far, all of them have been largely unsuccessful.

A study published in 2004 by the American Association of Cancer Research stated that PPAR agonists have

“…shown to have no effect on the proliferation of colorectal cancer cells” and “…under normal culture conditions, PPAR activation has no effect on cell growth”.  

Keep in mind that this study was done in rats given amounts of 400 mg a day and was abused and ran for hundreds of weeks to top it all off. Time and time again this study has been refuted and shown to be deeply flawed and inaccurate.

In a 2008 experiment done on human breast cancer and colon cancer cells, not only did the PPAR agonist GW 501516 prove to be safe for use, it has proven to inhibit cancer cell growth. The National Institute of Health has confirmed without a reasonable doubt that GW 501516 inhibits a multitude of cancers in human cells.

Over a decade of research studies on human PPAR beta (the primary target of GW) has only proven a decrease in cancer cells with extended use (up to two years). The confusion for these previous allegations of cancer growth were from results published in 1996 and have long since been abandoned due to new clinical research. The chemical compound has been dosed in human PPAR for a number of years and has only provided positive results on cancer treatments, liver function, and metabolic efficiency.

In all of the human studies done so far, there were no noticeable side effects at all while running GW.

Check out some of the studies and resources on GW 501516 for more info:

Stacking GW 501516

Read more about KONG

Stacking Cardarine means running it in combination with other compounds. What makes Cardarine stand out is it can be used with almost anything (cutting, bulking or recomping).

  • Bulking – clean up your gains and make that bulk cleaner while maintaining size.
  • Cutting – totally optimal when it comes to weight loss while holding on to muscle mass.
  • Recomping – perfect for building lean muscle and losing fat

The most common way to use Cardarine is in a triple stack involving LGD 4033 and MK 2866. You’ll have all the gains, endurance, fat loss and size gains by taking all three.


You can also take GW 501516 in the product KONG by Medfit Nutrition, which is a stack of 5 SARMs, and also includes 20 MG of cardarine in every capsule.


Where to Buy GW 501516 for Your Rat

There are a lot of places you can buy PPARs as well as SARMs in the U.S. However, you really have to be careful since a lot of these companies will sell you just about anything, falsely advertising it as GW.

I have used many different places online, but GW 501516 by Innovative Research Compounds is untouchable.

It’s formula is based on months of research and hailed to be the strongest, purest GW 501516 on the market. It’s the only place I’ll use.

Final Takeaway

After a lot of research and personal use, there is nothing I can recommend more than Cardarine. It is the king of all fat burners and reigning champion of endurance supplements. GW 501516 has received many rave reviews from its users. One user even said “…GW is probably the closest thing in research to a perfect formula. Stamina and fat loss is unreal!…” There’s no doubt this is the Clenbuterol of PPARs.

It’s true that most athletes and professional bodybuilders simply lack the endurance and cardio levels to get the results they want. With GW, you can actually add lean mass while reducing body fat…something you can’t do taking anything else. You’ll be able to lift longer and harder, and with an intensity never known to you before. This obviously is what it takes to get results and get them fast.

What are your thoughts on Cardarine? Have you tried GW 501516? Tell us by leaving your comments below.


References:

Grewal, Ajmer, Meenu Beniwal, Deepti Pandita, Bhupinder Sekhon, and Viney Lather. “Recent Updates on Peroxisome Proliferator-Activated Receptor δ Agonists for the Treatment of Metabolic Syndrome.” Medicinal Chemistry MC 12.1 (2016): 3-21. Web.

Shwarz, P. B., and J. H. Peever. “Result Filters.” National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 04 Sept. (2016).

Chen, Wei, Rong Gao, Xinni Xie, Zhibing Zheng, Haijing Li, Song Li, Fangting Dong, and Lili Wang. “A Metabolomic Study of the PPARδ Agonist GW501516 for Enhancing Running Endurance in Kunming Mice.” Scientific Reports. Nature Publishing Group, 06 May (2015).

Stephen, Ruth L., Mattias Gustafsson, Roger Tatoud, Barry R. Marshall, Deborah Knight, and Ewa Ehrenborg. “Activation of Peroxisome Proliferator-Activated Receptor δ Stimulates the Proliferation of Human Breast and Prostate Cancer Cell Lines.” Home. N.p., 01 May (2004).

Nihvcast. “Peroxisome Proliferator-Activated Receptors PPARs Treatment & Prevention Of Diseases.” YouTube. YouTube, (2012).

Ham, Sun Ah, Et Al. “Ligand-activated PPAR Upregulates Smooth Muscle Actin Expression in Human Dermal Fibroblasts.” Journal of Dermatological Science (2015): 186-95. Pubmed. Web. (2016).

Robertson, D. G., & Frevert, U. Metabolomics in drug discovery and development. Clin. Pharmacol. Ther. 94, 559–561 (2013).

Roberts, L. D. et al. The contrasting roles of PPARdelta and PPARgamma in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue. Genome Biol.12, R75 (2011).

Aguer, C. et al. Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells.PLoS. One. 6, e28536 (2011).

Qun, Z., Xinkai, Y., & Jing, W. Effects of eccentric exercise on branched-chain amino acid profiles in rat serum and skeletal muscle. J. Anim Physiol Anim Nutr. 98, 215–222 (2014).

50 thoughts on “GW 501516 (Cardarine): The Ultimate PPAR for Endurance and Fat Loss

  1. Kurt Bowden says:

    I’m thinking of purchasing Cardarine, LGD and OSTARINE for my research but my subject has to have a urine etg alcohol test monthly with a very low cut off at 60ng. Could you tell me the % of ETOH in each or bottle? My understanding excess ETOH hand sanitizer will show up if used frequently.

    Thanks,
    Kurt Bowden

  2. gary says:

    i have used this and what a difference it made on the very first time using it. i took it around 30 mins before i hit the gym and the energe i had was unreal, and this is after the first dose,

  3. J. Scrittore says:

    What if any are the risks (cardiac for example) for anyone over 75 taking this product just for the potential of reducing vicereal fat (abdominal) coupled with age-appropriate exercise and diet to achieve that goal?

    Tks

    • Chris Wallace says:

      Lab mice over the age of 75 days will encounter no problems with GW501516. The chemical compound does not increase the stress on the heart or blood vessels, instead it has been shown to decrease stress on cardiac cells by inhibiting added stress from overactive endoplasmic reticulum in the cardiac cells. in short, your lab mouse will be safe and will have a more efficient cardiac output.

    • Chris Wallace says:

      I haven’t found any adverse side effects for high doses of GW501516 in any recent research articles; I also haven’t found any significant increases in endurance or fat loss either. I’d say until there is information supporting a higher dose, you should stay at the 10-20mg dosing protocol.

  4. Noel says:

    Does cardarine need pct or support if i run it as a stand alone for 12weeks? And how long would I “off” cardarine before starting again?

    • Chris Wallace says:

      GW501516 can actually be run for up to two years. A 2016 study done by the NIH confirmed it’s safety and usage for long-term use. As for PCT, none is needed.

  5. Chris Wallace says:

    Unfortunately GW501516 can’t be sold in any stores in the USA legally due to new federal regulations. At the moment, it can be purchased on websites such as sarmstore1.com. It can only be sold in liquid form because the USA forbids the selling of encapsulated research chemicals.

  6. Fernando Martinez says:

    Chris Wallace – please help us less intelligent prospects how many drops is 10mg? I believe if this simple question is answered there would be no more questions asked. Again, please, how may drops equate to 10mg? Thank you

    • Chris Wallace says:

      Let’s say we have a vile of LGD4033 that says it’s 10mg/ml. The top of the bottle collects 1cc of fluid. 1cc is equal to 1ml which contains 10mg. For everyone out there confused about chemical measurements, just fill the fluid collector attached to the cap and it will give you the minimum daily dosage.

  7. Chris Wallace says:

    GW501516 should be given to your animal at the same time every day. This means even on rest days. Remember that this is not a pre-workout supplement, your animal should treat it with the same routine as a multivitamin

  8. Cardarine says:

    I keep seeing responses being referred to animals, is this bc technically its illegal for human consumption in the US? I’m wanting to get it, but can’t find any solid information regarding the legality behind using it. Is it “only” suppose to be used in research? and if so, does that make it illegal for human consumption?

    • Chris Wallace says:

      Yes. To sell this product like a supplement or to use this product as such would be equally as punishable as anabolic steroid use and and distribution.

  9. Curious says:

    If I’m dosing my mice with a protocol that includes a 19-nortestosterone compound, will GW-501516 help counteract the negative cardiovascular endurance effects of the 19-nortestosterone compound?

  10. Jeremy says:

    Can GW501516 be stacked with LGD4033? If so what is the recommended time frame for a cycle? I mainly do cardio and body weight exercises. Will this be beneficial for increasing endurance and leaning out? Thanks

  11. rat34 says:

    Hi
    Interested in doses for my rats
    Well trained subjects, novice users of these types of products so first use
    Want to assess effectiveness of concurrent use of cardarine and ostarine together over a 4 week period
    Can you advise most recommended and safe dosage for 34d old rat
    would a liver supp/AI/pct be of benefit/needed for this type of regime or not.
    Appreciate your help as a first time researcher. thanks

  12. Gareth Roland Davies says:

    Totally confused by all of this. I have a hypothetical rat (called Roland) Roland has eaten too much crap over Xmas and has the January gym fever, he thinks this is the year he will stay disciplined in the gym. He’s a supplemental novice and wants to know how to start out with SARMS. Can someone help him as a beginner please. What should he take. Thanks

  13. Rat38 says:

    Hi my is being tested with ostarine currently week 3, 30mg a day the rat is very happy and strong. At what point can I add to my test subject gw1516 and s4 to the stack?

  14. Mohanad says:

    Hello I’m 160 height and weigh approx 65 kg I’ve been working out for a while and now i’m thinking to use this product I see so many products in the website can someone with experience advise me on which product is best for me and how to use it dosage and how many times a day a week and for how long can I use it and cycle it off really need help here thanks in advance

    • MCap says:

      No, not usually… Job drug screens are for elicit drugs like marijuana, cocaine, narcotics, etc. …however, they will show up on sport drug testing.

  15. hoss says:

    Just finished a month on 20mg daily…ok so first week on it i felt unstoppable i went from doing six sets to ten sets and even added more execises witch felt great as i was doing them but the after math was not so good..I lift on the heavy side and ended up beating my body up so bad the rest of this month ive been recovering? ??? Ive been hitting the steel for 5 months steady prior to this..low carbing feeling good..the last two weeks on this ive felt like crap..but did lose around 8lbs of fat

  16. David Wagner says:

    Hello,

    my rat is obese, no other way to put it. average hight and is 330 down from 368 with the help of HGC diet I put him on. Will the recommended dose of 20mg a day help my rat to burn off the stored fat? I have seen some reviews where rats in decent shape showed no fat loss, but I have not seen any directly aimed at obese rats. Any info is appreciated.

  17. DW says:

    I have an obese rat. Very obese no training at all. Would the normal recomended 20mg/day dose work to cut fat from the fat rat?

    Regards,
    DW

  18. Mélan says:

    I am a 30 year old woman who has 50 pounds to lose. I do boxing 3x a week. What sarms do you advise me? Can I take the GW5015-16 alone or do I have to combine it with something else?

  19. Chris says:

    Hi Chris, I am an endurance triathlete (full and half distance Ironman races, age grouper). 39 yrs old about 170lbs just starting training for me 3rd full distance IM. Will be down to about 160lbs by time training program is done. I’m not really looking to gain mass, but I’ve put on about 5-7 lbs of muscle the last 9 months mostly in my legs and don’t want to lose it…I’ve read the studies, I’m looking to try the GW in some form. Is the KONG product a good way to go for my needs? Ideally, I’m looking for something that will help me build a stronger base of endurance, push my limits of VO2 max and FTP, increase watts on the bike, decrease my run splits and most importantly, help me to recover quicker after heavy training blocks…Hoping to qualify for Kona in the next 5 years. Appreciate your feedback.

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