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LGD 4033 (Ligandrol)


Chemical Name: 4 – ((R) -2 – ((R) -2,2,2-trifluoro-1-hydroxyethyl) pyrrolidin-1-yl) -2-trifluoro-methyl) benzonitrile
Other Name(s): Ligandrol, LGD 4033, VK-5211, LGD, Anabolicum
Molecular Name: C14H12F6N2O
Half Life: 24 hours, depending on individual

LGD-4033, known also as Ligandrol and Anabolicum, is the strongest orally bioavailable, non-steroidal, selective androgen receptor modulator (SARM) currently on the market.

Popular with athletes, power lifters and body builders for its ability to both bulk and cut, Ligandrol produces steroid-like results without the side effects.

It’s considered an excellent supplement for those looking to recomp: reduce their body fat and increase lean muscle mass.

From a medical perspective, Ligandrol is being studied to treat conditions such as muscle wasting linked with acute and chronic diseases, age-related muscle loss, Osteoporosis and cancer.

Let’s take a closer look…

History Behind LGD 4033

LGD-4033 was originally discovered by Ligand pharmaceuticals and is currently under development by Viking Therapeutics as VK5211.

From the start, LGD-4033 has been anticipated to yield the healing benefits of testosterone with better safety, admissibility and patient acceptance due to tissue-selective mechanism of action and its oral form of administering.

How it Works

Ligandrol works in the same way as other SARM’s: by selectively activating androgen receptors to promote anabolic activity exclusively in muscle and bone.

New to SARM’s? Click here for the beginner’s guide to SARMs for everything you need to know.

Studies show [1] that LGD-4033 has a high affinity muscle and bone AR’s rather than prostate, liver or sebaceous glands, which makes it an ideal SARM for building and preserving muscle mass and bone mineral density.

Clinical Trials

Since its initial discovery, two phases of clinical trials have been completed to study the application of LGD-4033 for muscle and bone growth.

Clinical Trial Phase 1: Effects on Lean Body Mass & Muscle Strength

The first phase of the clinical trial involved 76 healthy male adults who took a placebo or 0.1mg, 0.3mg, or 1.0mg of LGD-4033 for a 21-day period. [1] The study observed the effect of Ligandrol on lean body mass, muscle strength, stair-climbing power, and sex hormones and the results are extremely promising.

Read the study here, or read on for everything you need to know about LGD-4033. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111291/

Clinical Trial Phase 2:

The second phase clinical trial is currently underway by Viking Pharmaceuticals to investigate LGD-4033’s ability to benefit individuals recovering from hip fracture surgery.

Ligandrol’s ability to stimulate and preserve lean body mass, improve muscle strength and improve bone mineral density is favourable for elderly individuals most at risk of falls and morbidity associated with hip fractures.

Why YOU Should Take Ligandrol: The Benefits

There are 7 primary benefits that have been observed in both initial studies and user-reported reviews of LGD-4033…

WEEK 5:

That’s when I started to notice a slightly lean body mass gains. My upper body looked fuller, rounder and more muscular. My goal isn’t really to gain size in legs because I naturally have good leg muscles.

WEEK 6:

This is the time when I started to see increases in my lifts and I kept gaining muscle mass.

– WayneLee

https://realpeptide.com/forum/6457-lgd-4033-time-experience.html

  1. LGD-4033 increases lean muscle mass. The clear-cut primary benefit of supplementing with Anabolicum is its ability to increase lean muscle mass without increasing fat when bulking.The Phase 1 trial showed that participants taking 1.0mg of Ligandrol gained on average 2.66lbs (1.21kg) of lean body mass over the 21-day period. This increase was dose-dependent, meaning the more LGD-4033 taken, the more lean muscle mass was created. [1]NB: Recommended dosage is 10mg per day. We do not advocate going higher than this dose.
  1. LGD-4033 may improve strength and stamina. One key study measured participants stair-climbing speed and power as an indicator of muscle strength and endurance. Results from the 21-day study indicated a trend towards dose-related improvement of stair-climbing speed and power thanks to LGD. [1]Real users have noted an increase in muscle strength and stamina while cycling Ligandrol, which correlates with the increase in lean muscle mass seen in studies.

USER REVIEW

I have gained a pretty good amount of strength from this cycle. My core lifts have increased by 20-25%.

– TikTak

https://realpeptide.com/forum/6270-lgd-experience.html

  1. LGD-4033 selectively targets muscle and bone tissue. As a true SARM, LGD targets the AR almost exclusively in muscle and bone tissue, which is why it is being studied to prevent and treat caxechia, sarcopenia, osteoporosis and older individuals recovering from hip fractures.Studies show that, even though there was clear androgenic activity in muscle and bone tissue, the prostate-specific antigen did not change significantly when taking the correct Anabolicum dosage.
  1. LGD-4033 may increase fat loss. LGD has amazing anti-catabolic activity, which means it prevents the breakdown of hard earned muscle. This is why lean body mass has been reported in some users to increase even during a caloric deficit.Ligandrol also indirectly reduces body fat by increasing muscle and bone cells, which are more metabolically expensive to maintain than fat cells. By increasing muscle mass, an increase in the catabolic activity metabolism is seen, which results in easier fat loss.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661116/Many users report stacking LGD-4033 with S4 (Andarine) to support simultaneous bulking and cutting.
  1. LGD-4033 boosts mental well-being. Many users have reported feeling positive, strong and a sense of ‘alpha’ when taking Ligandrol. This state of mental wellbeing and what some have called a slight feeling of ‘aggression’ benefits their lifts in the gym as it improves their competitive streak. Just be sure not to get too competitive and keep your lifts smart and safe.
  1. LGD-4033 may help patients recover from hip fractures. Phase 2 of the clinical trial of Ligandrol is currently underway. Viking Pharmaceuticals noticed that older individuals are at higher risk of suffering a hip fracture and, due to sarcopenia (the natural decline of muscle mass after the age of 30), it’s harder for individuals to both retain and build lean muscle mass.Combined with a hip fracture, and the rate of morbidity due to complications after a fall increases.A supplement such as Ligandrol, which helps increase bone mineral density as well as increase lean muscle mass without the side effects of traditional treatments such as steroids is a promising treatment for an otherwise overlooked population.
  1. LGD-4033 may treat muscle wasting caused by cancer. Anabolicum’s Phase 1 clinical trial showed promising results for building and preserving lean muscle mass in healthy young men, which has lead Viking Pharmaceuticals to investigate how LGD could be used to treat caxechia (muscle wastage) caused by cancer. Trials are currently underway (2016). [2]

The Side Effects of LGD 4033

As with all supplements, some side effects have been noted by both users of Ligandrol and during studies. However, it’s worth noting that side effects of LGD-4033 appear to be not only minimal and reversible, but outweighed by the benefits.

The primary Clinical Trial Phase 1 showed that LGD-4033 was well-tolerated and safe at all doses.

However, some side effects reported by users online include:

  • Headaches
  • Hair growth as well as shedding
  • Nausea
  • Fatigue
  • Muscle Pumps

However, whether these side effects can be attributed to Ligandrol is hard to say, as some users do not purchase their SARMs from reputable sources.

Keep in mind that results and side effects vary by individual, particularly as a minimally-studied, non-FDA approved supplement.

Bottom Line: There have been no serious or long lasting negative effects reported as a result of taking LGD 4033.

And with it’s 24 hour half life, anything you DO experience will go away pretty quickly. I also recommend you limit each cycle to a maximum of 6 weeks and take a full month off before you take it again.

Don’t be stupid, or irresponsible, and always be aware of how your body is responding to it and you’ll be okay.

Does LGD-4033 cause temporary suppression of testosterone?

An interesting side effect of Ligandrol is a dose-dependent suppression of total testosterone and hormone-binding globulin levels. Although Ligandrol increased lean body mass, the study showed testosterone suppression from baseline to day 21 of the three-week study. [1]

However, once LGD-4033 was discontinued, testosterone levels returned to their normal baseline by day 56. A mini-PCT (Post Cycle Therapy) should assist the body in returning to baseline.

USER REVIEW

My ex was tiny like you. I put her on 5mg a day of LGD and she had really good results, her immune system also got way better and she no longer was so underweight…she put on some quality lean mass.

– Stevesmi

https://www.evolutionary.org/forums/anabolic-steroids-peds/sarms-women-54130.html

Dosing Guidelines

Benefits have been documented with dosages as little as 3-10mg every 24 to 36 hrs. Research subjects have been know to tolerate therapy with notable benefits after 2 weeks with improvements continuing for up to 5 months (20 weeks). Note that research recognizes a increase in tolerance after 3 months with benefits continuing to decrease.

Many male users report the upper ideal limit for LGD to be 10mg per day in the morning for twelve weeks.

Although some women have reported using LGD-4033, it has been suggested that it may cause masculinisation lower doses are recommended. Females are advised to stick to an upper limit of 5mg per day.

The chart below is a simple guideline that will work for 99.9% of people:

LGD 4033 Dosing Guidelines
LGD 4033 Dosing Guidelines

For Bulking: A protein-rich diet is also necessary as well as higher caloric intake if you plan to beef up by at least 10 lbs.

For Cutting: Use LGD-4033 with SARMS triple pack (GW-501516, S-4 and LGD-4033) to make it more effective as you are aiming to add more size while cutting fat. Suggested dosage is 3-5 mg a day for 8 weeks.

For Recomping: LGD-4033 is best used for recomping. Many users have said that they’ve observed a boost in lean body mass and fat loss. Using it together with other SARMS such as GW-501516 or Cardarine will give you a stronger and better recomp. Suggested dosage is 5-8 mg per day for 8 weeks.

In the studies done on Ligandrol they are using sometimes as little as 1mg and still seeing pronounced muscle gain. This randomized, double-blind study showed that it was safe even up to 22 mg per day for average people.

Post Cycle Therapy (PCT)

Post Cycle Therapy (PCT) is required when taking SARMS to help preserve muscle gains, prevent fat accumulation, maintain mood and motivation, and retain strength in muscles. Cycling also helps to allow hormone levels to return to their natural state in order to prevent unwanted dependency.

Typically, a PCT will last the same duration as supplementation. So if a user supplemented with a hormone for 12 weeks, a PCT of 12 weeks would also be required to bring their hormones back to baseline.

But do I need a PCT when taking SARMs?

Typically, SARMs do not disrupt hormone levels in the body, which means that a traditional PCT is not necessary. However, studies and user reviews show that LGD-4033 temporarily decreases testosterone levels. These levels are quickly reversed when supplementation is stopped, and a mini PCT can help speed up the recovery process.

Where to Buy LGD 4033 Online

 

Due to the recent ban of SARMs, you can no longer get them from some of the reputable sites that were available back then. However, for the remaining ones, sarms4you.com is the best place to get the purest form. However, as the compound is yet to be approved for human consumption, the SARM industry is unregulated and it’s important to do your due diligence in finding a reputable supplier. A recent study suggests that 52% of SARMS purchase online were incorrectly labeled and did not contain the correct ingredients.

https://www.ncbi.nlm.nih.gov/pubmed/29183075

 

Stacking

Although great on its own, LGD-4033 can be stacked with other SARMs for added benefits tailored to your individual needs, such as bulking or cutting.

Many users suggest stacking LGD-4033 with RAD140 (Testolone), MK677 (Nutrabol) and S4 (Andarine) for a 12-week bulking cycle that boosts growth hormones, burns fat and improves sleep.

Find out more about RAD140 (Testolone), MK677 Nutrabol and S4 (Andarine).

Looking for the ultimate SARM stack? KING provides a well-rounded selection of SARMs and prohormones chosen to work synergistically.

KING

 

Final Review: Our Opinion on Ligandrol

Renowned in the bodybuilding industry as the strongest SARM on the market, LGD-4033 is considered one of the best supplements to build lean muscle without the side effects of steroids.

Thanks to its anti-catabolic plus anabolic activity, Ligandrol is perfect for recomp as it allows users to both bulk and cut simultaneously. This makes it a stand out supplement in your bodybuilding toolkit that stacks well with other SARMs for incredible results.

Where LGD shines compared to other SARMs is the level of human clinical studies. Although it has not been approved for human use and trials are still being investigated, it has already been proven in some studies to increase lean muscle mass in humans rather than rats or primates.

Additionally, these trials showed promising results in as little as 3 weeks, and anecdotal user reviews support quick gains that last after a 12-week cycle is complete.

Because it selectively targets muscle and bone tissue, LGD-4033 doesn’t have the side effects caused by steroid use.

The only obvious concern with Ligandrol is the dose-related testosterone suppression that needs to be monitored while cycling. However, the fast return to baseline testosterone levels once a cycle and mini PCT has been complete is a huge drawcard for LGD.

If you’re looking for increased endurance, stamina, fat loss and muscle gains without the side effects of testosterone, LGD-4033 is a great choice for your next cycle.

Testimonials

I love before and afters. I also have a big curiousity for the kinds of results other people get taking various compounds.

Here are some of the reviews I have found from people who have cycled LGD 4033 and what they have to say…

I took an 8 week cycle of LGD 4033 I’ve been off now for a week I’m still getting great pumps I still kept all the strength I gained on my pct now I did experience a little upset stomach a few times through my 8 week cycle butt nothing else LGD 4033 is the best thing out there I gained 15 pounds of muscle I’m 43 now and felt like I was back in my twenties I had awesome pumps and massive gains with this product. – Max Limone

One user even posted some videos of him lifting more than he usually did at the gym:

In Terms of Muscle Gains

People who have already given LGD 4033 a go share that its anabolic effects are not instantaneous, but can be truly felt in just a few days’ time. They also experienced a noticeable change in muscle hardness and vascularity while using the product.

muscle1

muscle3

 

muscle6

 

FAQs

Clinical trials are still being performed, and LGD-4033 is not FDA approved for human use. However, existing studies and user-reported reviews are promising and state that LGD is safe and well tolerated over a range of doses [1].

Initial studies showed results within a 21-day trial period on healthy male volunteers. Many users report muscle mass results after 4 weeks, although individual results may vary.

Most user-reported reviews suggest taking LGD-4033 for 12 weeks before taking a mini PCT for 4 weeks.

Phase 1 clinical trial and anecdotal user reviews show testosterone suppression that quickly reverses once the cycle is complete.

Most users suggest taking LGD in the morning as it may increase stamina. Some users report mild insomnia, which makes taking Ligandrol in the a.m. a wise decision.

Yes, LGD-4033 is legal to purchase from a number of research companies for research purposes. It is not yet sold for human consumption.

No, LGD is not a steroid and its primary androgenic action is to selectively target muscle and bone cells instead of the prostate.

Anecdotal female reviews show promising results at the maximum female dosage of 5mg/day.

If you’re genetically prone to it, Ligandrol could cause hair loss on as low as 10mg a day. Just reduce your dosage even further, and it will probably stop.

We strongly advise taking a PCT due to the testosterone suppression that has been confirmed in both clinical trials and reported by users. Rest assured that these levels will return to normal once the cycle is complete, but a PCT will help you return to baseline faster.

Yes! In fact, I think it’s a great stack to take together. Since SARMs are non methylated, you won’t have to worry about stacking your Ligandrol whether it’s with MK 677, RAD 140, or any other SARM.

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References

1. Basaria, Shehzad et al. “The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men.” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 68.1 (2013): 87–95. PMC. Web. 17 Mar. 2018. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111291/

2. Handlon, Anthony L. et al. “Optimizing Ligand Efficiency of Selective Androgen Receptor Modulators (SARMs).” ACS Medicinal Chemistry Letters 7.1 (2016): 83–88. PMC. Web. 17 Mar. 2018. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716610/

27 Comments
  1. A P says

    Can I just take LGD4033 on my leg days. So twice a week. My leg days are Tues and Sat. All other body parts are good. I just have bird legs. I have been working out for over 1 year and I cant seem to grow my legs.

    1. Chris Wallace says

      Unfortunately I will not be able to answer any questions related to human use. These products are research chemicals and are not meant for human consumption. I will on the other hand answer questions related to muscle growth in your lab animals.

      1. Dex says

        Hey Chris

        I am a university student and I have been doing extensive research on imaginary animals.
        How long should the imaginary cycle be and is an imaginary PCT required?

        1. Chris Wallace says

          Well this imaginary PCT should be 4 weeks. Normally I would suggest Nolvadex but if I were to suggest a specific brand, eliminate from Olympus labs UK is also very good. Make sure your animal is taking it during your last 2 weeks and continue for 4 more weeks afterwards. Remember that it isn’t recommended to cut for at least one month after your animal completes a bulking cycle.

          1. Mr. Bubbles says

            Just to confirm, you’re saying that the animal should cycle on to a PCT in the last 2 weeks of the LGD 4033 cycle?

  2. conn says

    Would I need to use a PCT,after an 8 week cycle on
    a tri stack of,,
    GW 501516 ,LGD4033,MK 2866 (or S4)
    Thanks

    1. watcher says

      don’t do an 8 week cycle…do a 4 to 6 week and make sure you have pct on hand

    2. Warj1990 says

      S4 will shutdown natural fairly quickly, so YES.
      GW, LGD, MK, no your fine for 8 weeks. Just take 2 weeks off and repeat if desired.

  3. Husky Trainer says

    Hello Chris Wallace or SARMSstore comments moderator:
    I have some champion Siberian Huskies, they are record holders in pushing and pulling competitions for dogs. I would like to provide them with a boost in strength for their next events. I was going to try LG-4033. I have a couple of 220 lbs huskies and three 132 lbs female huskies. I was going to give the males 10mg and the females 5mg. Does this sound about right. Also, I keep reading about cycling. As I understand cycling as it applies to oral testosterones that is because of the alkyd molecule at the 17a position which caused liver damage but allowed the testosterone to make multiple passes thru the liver.
    Since LG-4033 is a SARMS, there is no Alkyd molecule to cause liver dysfunction, correct? Is it really necessary to cycle the SARMS then? I really care about my Huskies and only want the best for them.
    These are serious questions and I hope you take the time to respond.
    Thanks, Husky Trainer.

    1. Warj1990 says

      Female husky should enjoy MK-2866. It helps for stage shows without bulking.
      Male husky should enjoy LGD-4033.
      Usually one would administer a dose for 3 weeks (say 10-15mg) then up for 3 weeks (say total 15-20mg) then up it for the final two weeks (say total 20-25mg).

      In order for the body to be responsive a two week period should be taken to allow this to clear and the body to balance. Then repeat again. Keep feedback on mood, feeling and results and target that XX mg range for this cycle.

      As always (with anything) nutrition is key for gains or losses, SARMS help.
      Happy training.

  4. Rodolfo Vargas says

    Hi! I have a question, I am working on a lab research and would like to know what are the expected results in terms of gains for LGD 4033. Since the very 1st dose, when will the results come? What would be the increase (of muscle) per week?

    1. Warj1990 says

      This is a loaded question. I will attempt to answer it.

      First question: are you training? No…come back in 6 months of gym workouts.
      Are you eating properly for your goals? Um…maybe…come back in 2 months.

      Ok, so your back…Now you know what working in the gym is and what it takes to eat to gain muscle or slim down (bulk or cut)…your ready for boosters (SARMS).

      The first 2 weeks expect little results. Your lifting weights will be about the same as well as body weight. The 3rd week on your going to start to feel hungry often. You will also notice you can lift more weights like they are really lighter (as an example squats and deadlifts moving up 30 lb a week fairly easy). So by week 6-8 you should be up 100+ lb on your major lifts.

      While pushing yourself in this manor you can expect about 6-10lb of muscle mass.

      Now if your eating potato chips, kicked back watching movies…expect maybe 1 lb.

  5. Fab says

    Hi excuse mt ignorance what is PCT

    1. Ben says

      post cycle therapy

  6. RONKLE says

    Yes, was taking 10mg/day and after the 4th week my hair started to fall out moderately. I cut back and it stopped.

    1. Mark says

      The hair loss is only if you are genetically prone. It will not cause hair loss in those that do not have that genetic marker.

  7. Aaron C Mays says

    Dont need pct

    1. Mortane says

      Always use a pct

  8. Michael says

    I’m about to start the same cycle brotha I just bought both of them. 3 tabs a day of each I’m curious of to how it’ll work. How was it for you?

  9. Ricky says

    So you’d say it’s safe for people to take?

  10. Davis says

    Chris, if the lab rat in my experiment is being given a low dose testosterone of say 200mg/week, how would your experiments suggest that LGD-4033 might interact with the testosterone? Do you suspect the interaction would be beneficial?

    1. Warj1990 says

      At 200mg/wk you are on TRT. If your trying to bulk old school (Test injection) then it should be 500mg/wk for results at 12weeks (notice how that matches most cut and bulk routines as well 😉
      As to SARM stacks with TRT (in this case) Rad140 has been shown to keep sides to a minimum.

  11. Berry says

    Hello Chris,
    My rat does not have time to work out. He is on 24 hr call and is up at all hours of the day and night. He does have a very physical lifestyle in his cage. About 15 miles a day walking as well as lifting heavy objects. He has been trying to loose the extra weight by eating right. He would like to know if this would be the right product to use to shed the fat as well as retain and build muscle mass. He is currently prescribed testosterone from his doctor. Thank you for your time.

  12. Warj1990 says

    ProHormones need to be tossed in the trash…Just saying they have lots of sides and you would be better off with real Test injections.

    SARMS are different. LGD made my rat hungry. Also, resting on a shoulder at night caused lots of pain when waking up- so sleep was affected. Needed to get used to face down or face up for rest. Other than those all good. My rat gets really lethargic around 180lb. Ending this cycle weigh in at 186 and still felt great.

  13. Warj1990 says

    6 to 8 week… no your rat will be fine.

  14. Warj1990 says

    Not a liver issue in any way. Both should be taken once per day at the same time each day.

  15. Warj1990 says

    Simply put: These are not FDA approved. Secondly if they were you would need a Dr. prescription to obtain them.

    SARMS can only be sold as research chemicals or the FDA will shutdown with massive fines.

    At this stage of life with a “sue happy” nation it is more profitable to sell “research chemicals” and not worry about lawsuits against companies. Enjoy testing on your “rats”

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