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LGD 4033 (Ligandrol)

Chemical Name: 4 – ((R) -2 – ((R) -2,2,2-trifluoro-1-hydroxyethyl) pyrrolidin-1-yl) -2-trifluoro-methyl) benzonitrile
Other Name(s): Ligandrol, LGD 4033, VK-5211
Half Life: 24 hours

LGD-4033, known also as Ligandrol, is a non-steroidal SARM that binds with the AR, producing steroid-like results and revolutionary potential in medical science.

It’s in a group of androgen receptor ligands that are tissue selective, created to cure muscle wasting linked with acute and chronic diseases, age-related muscle loss, Osteoporosis and cancer.

Developed by Viking Therapeutics, LGD-4033 is anticipated to yield the healing benefits of testosterone with better safety, admissibility and patient acceptance due to tissue-selective mechanism of action and its oral form of administering.

As of now, LGD-4033 is the strongest of all the SARMS in terms of the performance enhancement benefits & it’s ability to promote muscle growth.

The Science Behind LGD 4033

As we mentioned, since Ligandrol is a SARM, it works in mostly the same way. By tying androgen receptors in a very selective and specific way, it is able to promote an anabolic activity level EXCLUSIVELY in the muscle and bone. This is all without harmfully effecting the prostate, liver or sebaceous glands like steroids would which gives it a huge advantage.

If you’re not familiar with selective androgen receptor modulators, you can click here for the beginner’s guide to SARMs for a better understanding.

Why YOU Should Take Ligandrol: The Benefits

Many athletes and scientists have been excited about it’s potential in sports and bodybuilding, and has since become very popular.

So what will you get out of taking a cycle of Ligandrol?

A Phase I study was recently done, and here are the benefits of Ligandrol that were experienced that make it so popular:

Increased Muscle Tissue & Weight Gain

Unlike prohormones or anabolic steroids, you’re not going to put on 15-20 lbs taking LGD or any SARM for that matter.

However, most people do report gaining 1.5-2 lbs in a single week while on cycle. In addition to that, scientific studies have shown that a 21 day period was enough to show a dramatic change in lean muslce tissue.

You might put on close to 10 lbs if you really do things right, but this will be lean, smooth muscle tissue with no to no water bloat or joint pain.

Maintain a high protein, high calorie diet and you’ll do just fine.

Improves Strength Levels

Along with muscle gain, LGD will rapidly increase your strength levels as well, sometimes more quickly than the weight you gain.

In fact, the improvements in muscular tissue that LGD 4033 helps promote could be said to what causes the increase in size and weight.

Perfect for Recomp & Anti Catabolic

LGD 4033 has amazing anti catabolic benefits, which basically means that it switches your body’s primary source of fuel to body fat and helps to prevent muscle wasting.

So whether you’re putting on size or on a strict diet to cut weight, Ligandrol will optimize your results either way.

Since LGD help shred body fat while building muscle, it will truly shine if you want to transform your physical appearance.

Ligandrol: Cure for Osteoporosis?

One of the most revolutionary things about Ligandrol, aside from it’s obvious aesthetic benefits, is it’s ability to incease periosteal bone formation.

This means stronger bones and tendons. So, when you combine that with a simultaneous improvement in muscular strength, you can see how LGD 4033 is a compound that can make some serious difference for someone suffering with many forms of muscle, bone or tendon complications.

Cancer Cachexia

Without diving too deep into scientific research, I wanted to also include our findings about Ligandrol that have shown improvements in cancer cachexia, common with people who have AIDs or with cancer.

The Side Effects of LGD 4033

Now that we’ve talked about all the good things you can get by taking a SARM like Ligandrol, you might be wondering what kind of adverse effects you might experience on cycle.

The good news is that they are MINIMAL, at least AS OF NOW (which I want to stress)

Because LGD 4033 is so new, scientists are still learning about possible long term effects, and what we know now can always change in a moment. SARMs are so exciting because they’re able to accomplish many medical benefits without the negative effects of testosterone therapy or anabolic steroids.

LGD is no exception.

In fact, it has even been shown to be safe all the way up to 100 times it’s normal dose.

Does Ligandrol Decrease Testosterone Levels?

Despite some claims that LGD 4033 will raises test levels, the research has actually shown the opposite. However, don’t be alarmed. They went back to normal within a few weeks.

Try getting those kinds of benefits using prohormones.

Other side effects reported by people in forums and all over the internet include:

  • Fatigue
  • Nausea
  • Hot flashes and increased sweating
  • Muscle Pumps
  • Hair Loss
  • & Headaches

It’s worth noting that there even the mildest of side effects like the ones above are rare, and most of them haven’t been proven to be a direct cause of Ligandrol.

Bottom Line: There have been no serious or long lasting negative effects reported as a result of taking LGD 4033.

And with it’s 24 hour half life, anything you DO experience will go away pretty quickly. I also recommend you limit each cycle to a maximum of 6 weeks and take a full month off before you take it again.

Don’t be stupid, or irresponsible, and always be aware of how your body is responding to it and you’ll be okay.

Where You Can Buy Ligandrol Online

Buying LGD 4033 online is a pretty quick and easy process. There are 100s of companies out there currently offering the SARM to anyone who wants to use it, either for themselves or for their rat at home.

Powersupps UK right now has the best LGD supplements I’ve found, and I have so far used many different products over the years.

I highly recommend the KONG which is FIVE SARM STACK that includes 10mg LGD in every capsule.

For the liquid version of Ligandrol, you can buy some at Innovative Research Compounds for only $65. This is the only source I recommend right now, as well as most people on Reddit or in the underground community.

Their stuff is pure gold.

Dosing Guidelines

Based on some latest studies and experiments conducted, Ligandrol can enhance lean muscle mass and decrease body fat. Also, it can boost strength for better and more challenging training performance, recovery and overall health.

Benefits have been documented with dosages as little as 3-10mg every 24 to 36 hrs. Research subjects have been know to tolerate therapy with notable benefits after 2 weeks with improvements continuing for up to 5 months (20 weeks). Note that research recognizes a increase in tolerance after 3 months with benefits continuing to decrease.

For Bulking

Suggested dosage is 7-10 mg a day for a total of 15 to 20 mg for 8 weeks is a good guideline. A protein-rich diet is also necessary as well as higher caloric intake if you plan to beef up by at least 10 lbs.

For Cutting

Use LGD-4033 with SARMS triple pack (GW-501516, S-4 and LGD-4033) to make it more effective as you are aiming to add more size while cutting fat. Suggested dosage is 3-5 mg a day for 8 weeks.

For Recomping

LGD-4033 is best used for recomping. Many users have said that they’ve observed a boost in lean body mass and fat loss. Using it together with other SARMS such as GW-501516 or Cardarine will give you a stronger and better recomp. Suggested dosage is 5-8 mg per day for 8 weeks.

In the studies done on Ligandrol they are using sometimes as little as 1mg and still seeing pronounced muscle gain. This randomized, double-blind study showed that it was safe even up to 22 mg per day for average people.

Our Opinion on Ligandrol

If you’re going to go with a SARM, my opinion is that LGD 4033 is actually going to be your best bet.

It’s considered the king of selective androgen receptor modulators, and is the strongest and most effective option right now. It can also be taken by both men and women.

With all of it’s endless benefits, potential in medical science and lack of side effects, Ligandrol is a SARM I highly recommend for anyone trying to improve their performance in the gym.


I love before and afters. I also have a big curiousity for the kinds of results other people get taking various compounds.

Here are some of the reviews I have found from people who have cycled LGD 4033 and what they have to say…

I took an 8 week cycle of LGD 4033 I’ve been off now for a week I’m still getting great pumps I still kept all the strength I gained on my pct now I did experience a little upset stomach a few times through my 8 week cycle butt nothing else LGD 4033 is the best thing out there I gained 15 pounds of muscle I’m 43 now and felt like I was back in my twenties I had awesome pumps and massive gains with this product. – Max Limone

One user even posted some videos of him lifting more than he usually did at the gym:

In Terms of Muscle Gains

People who have already given LGD 4033 a go share that its anabolic effects are not instantaneous, but can be truly felt in just a few days’ time. They also experienced a noticeable change in muscle hardness and vascularity while using the product.







Although Ligandrol is considered for the most part side effect free, some women have reported developing more masculine features, so I’d be very careful and keep the dose low.

If you’re genetically prone to it, Ligandrol could cause hair loss on as low as 10mg a day. Just reduce your dosage even further, and it will probably stop.

It won’t affect your liver but a full PCT is advised after running LGD-4033. The suppression is higher than other SARMS (but lower than anabolics), thus the need for PCT.

You don’t need anything too extreme, like Nolvadex or Letrozole (but you can if you want!), but a product like Gainz Insurance would be good.

Yes! In fact, I think it’s a great stack to take together. Since SARMs are non methylated, you won’t have to worry about stacking your Ligandrol whether it’s with MK 677, RAD 140, or any other SARM.

  1. A P says

    Can I just take LGD4033 on my leg days. So twice a week. My leg days are Tues and Sat. All other body parts are good. I just have bird legs. I have been working out for over 1 year and I cant seem to grow my legs.

    1. Chris Wallace says

      Unfortunately I will not be able to answer any questions related to human use. These products are research chemicals and are not meant for human consumption. I will on the other hand answer questions related to muscle growth in your lab animals.

      1. Dex says

        Hey Chris

        I am a university student and I have been doing extensive research on imaginary animals.
        How long should the imaginary cycle be and is an imaginary PCT required?

        1. Chris Wallace says

          Well this imaginary PCT should be 4 weeks. Normally I would suggest Nolvadex but if I were to suggest a specific brand, eliminate from Olympus labs UK is also very good. Make sure your animal is taking it during your last 2 weeks and continue for 4 more weeks afterwards. Remember that it isn’t recommended to cut for at least one month after your animal completes a bulking cycle.

  2. conn says

    Would I need to use a PCT,after an 8 week cycle on
    a tri stack of,,
    GW 501516 ,LGD4033,MK 2866 (or S4)

    1. watcher says

      don’t do an 8 week cycle…do a 4 to 6 week and make sure you have pct on hand

    2. Warj1990 says

      S4 will shutdown natural fairly quickly, so YES.
      GW, LGD, MK, no your fine for 8 weeks. Just take 2 weeks off and repeat if desired.

  3. Husky Trainer says

    Hello Chris Wallace or SARMSstore comments moderator:
    I have some champion Siberian Huskies, they are record holders in pushing and pulling competitions for dogs. I would like to provide them with a boost in strength for their next events. I was going to try LG-4033. I have a couple of 220 lbs huskies and three 132 lbs female huskies. I was going to give the males 10mg and the females 5mg. Does this sound about right. Also, I keep reading about cycling. As I understand cycling as it applies to oral testosterones that is because of the alkyd molecule at the 17a position which caused liver damage but allowed the testosterone to make multiple passes thru the liver.
    Since LG-4033 is a SARMS, there is no Alkyd molecule to cause liver dysfunction, correct? Is it really necessary to cycle the SARMS then? I really care about my Huskies and only want the best for them.
    These are serious questions and I hope you take the time to respond.
    Thanks, Husky Trainer.

    1. Warj1990 says

      Female husky should enjoy MK-2866. It helps for stage shows without bulking.
      Male husky should enjoy LGD-4033.
      Usually one would administer a dose for 3 weeks (say 10-15mg) then up for 3 weeks (say total 15-20mg) then up it for the final two weeks (say total 20-25mg).

      In order for the body to be responsive a two week period should be taken to allow this to clear and the body to balance. Then repeat again. Keep feedback on mood, feeling and results and target that XX mg range for this cycle.

      As always (with anything) nutrition is key for gains or losses, SARMS help.
      Happy training.

  4. Rodolfo Vargas says

    Hi! I have a question, I am working on a lab research and would like to know what are the expected results in terms of gains for LGD 4033. Since the very 1st dose, when will the results come? What would be the increase (of muscle) per week?

    1. Warj1990 says

      This is a loaded question. I will attempt to answer it.

      First question: are you training? No…come back in 6 months of gym workouts.
      Are you eating properly for your goals? Um…maybe…come back in 2 months.

      Ok, so your back…Now you know what working in the gym is and what it takes to eat to gain muscle or slim down (bulk or cut)…your ready for boosters (SARMS).

      The first 2 weeks expect little results. Your lifting weights will be about the same as well as body weight. The 3rd week on your going to start to feel hungry often. You will also notice you can lift more weights like they are really lighter (as an example squats and deadlifts moving up 30 lb a week fairly easy). So by week 6-8 you should be up 100+ lb on your major lifts.

      While pushing yourself in this manor you can expect about 6-10lb of muscle mass.

      Now if your eating potato chips, kicked back watching movies…expect maybe 1 lb.

  5. Davis says

    Chris, if the lab rat in my experiment is being given a low dose testosterone of say 200mg/week, how would your experiments suggest that LGD-4033 might interact with the testosterone? Do you suspect the interaction would be beneficial?

    1. Warj1990 says

      At 200mg/wk you are on TRT. If your trying to bulk old school (Test injection) then it should be 500mg/wk for results at 12weeks (notice how that matches most cut and bulk routines as well 😉
      As to SARM stacks with TRT (in this case) Rad140 has been shown to keep sides to a minimum.

  6. Berry says

    Hello Chris,
    My rat does not have time to work out. He is on 24 hr call and is up at all hours of the day and night. He does have a very physical lifestyle in his cage. About 15 miles a day walking as well as lifting heavy objects. He has been trying to loose the extra weight by eating right. He would like to know if this would be the right product to use to shed the fat as well as retain and build muscle mass. He is currently prescribed testosterone from his doctor. Thank you for your time.

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