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The Ultimate Guide to Sarms

Have you heard of SARMS a.k.a. Selective Androgen Receptor Modulators? It’s dubbed as a steroid alternative that’s said to be the most efficient for cycling steroids and PCT (post cycle therapy).

Today, I’ll talk about SARMS and give you the 401 to help give you a glimpse on everything there is to know about it.

What are SARMs?

The topic of SARMs (or selective androgen receptor modulators) have been a controversial one since the early 90s when they were first introduced in mainstream science. Now this isn’t to say that SARMs haven’t been around long before this period. In the 1940s, steroidal SARMs have been used for medical use in multiple diseases including cancer, hypogonadism, osteoporosis, and a number of other diseases that affect muscle and bone wasting. These SARMs had a very strong effect on muscle building due to its “high affinity”, which in non-scientific terms means it’s attraction to a receptor is high and that is what makes a chemical reaction in the body more powerful.

Unfortunately, steroidal SARMs came with side effects such as estrogen conversion causing gynecomastia (puffy sensitive nipples in men), decreased libido, and damage to the liver and kidneys (related to its methylation). Another side effect was that steroids can change the DNA of multiple cells such as the prostate and heart cause them to enlarge.

KONG is a 5 SARM stack made by Musclegen Nutrition that you can still buy today. Learn more here.

Steroidal VS Non Steroidal SARMs

In the early 1990s, scientist created a non-steroidal version of these SARMs by making them protein based. The difference between these two types of SARMs is most easily described as a lock and key system. The cells in the body act as locks and the binding sites of the cells are like key holes. Steroidal SARMs have the ability to act like a master key unlocking every cell to promote protein synthesis and growth, even in cells you don’t want to “unlock”.

Nonsteroidal SARMs are designed specifically for one type of lock, therefore, it will only affect areas of the DNA that prevent muscle and bone wastage while also promoting growth in these areas.

Nonsteroidal SARMs have been used for bodybuilding, powerlifting and a multitude of other sports since the start of it popularity. Their benefit to side effect ratio have been tested since the 1990s with no evidence suggesting harm. This breakthrough in scientific technology continues to suggest SARMs is the future of anabolics and will eventually replace steroid therapy.

Now this is not to say that nonsteroidal SARMs are the answers to all our problems. Although a protein based SARMs have very limited side effects with large benefits for strength and muscle gains, they also require a much longer period of use and cannot yet compare to the effectiveness of a steroid. The comparison of benefits and unwanted side effects have been researched for decades.

Unlike testosterone cypionate, SARMS are more than 200 times more powerful in muscle stimulation and 80 times more selective for muscle.

SARMS vs. Prohormones

Prohormones were the first ones introduced to the market. However, steroids or testosterone supplements don’t have the muscle growth effects of authentic steroids and they carry the same adverse side effects making them unsafe for human use.

Meanwhile, SARMS are an upgrade of anabolic steroids. It can be administered orally, minimizing the effects in testosterone blood levels. SARMS are also believed to cure various diseases which steroids and other medicines treated earlier. It also shows promise to replace androgen which can yield similar desirable results on muscle tissue as steroids.

According to a study conducted by the World Anti-doping Agency (WADA), approximately tenth of the worlds athletic population uses SARMS (particularly Ostarine) to enhance their body and performance (which is considered a safe performance boost).

Studies have shown the ability of SARMs to increase muscle and bone mass dramatically in animals while having no adverse impact on the prostate. Phase I trials of SARMs in humans have also reported significant increases in lean muscle mass. The two most talked about SARMs among bodybuilders are SARM S-4 a.k.a. Acetamidoxolutamide and SARM S-1: a.k.a. Ostarine or MK 2866.

How Do SARMS Work?

As we age, our endurance, power and skeletal muscle mass deteriorates due to the loss of type 2 muscle fibers. This hinders individuals to function normally. With SARMS, skeletal muscle mass and strength in androgen-deficient people can be enhanced.

There are 2 types of administering SARMS – orally or in injectable dosages. The anabolic effect is expected to be the same as testosterone. Moreover, it’s also said to produce dose-dependent improvements in bone mineral density and motorized strength apart from the ability to decrease body fat and increase lean body mass.

SARMS link to the same receptors that old steroids such as Dianabol and testosterone would connect to, but minus the drawbacks and side effects of traditional steroids and prohormones. This is a fresh start in the advancement of muscle pharmacology as SARMS can help enhance muscle mass, while helping you reduce body fat and boost athletic performance beyond your imagination.

The Most Popular SARMS

There are many SARMS, but here are the 4 main SARMS that are currently offered and most applicable to athletes, bodybuilders and fitness enthusiasts:

  • LGD-4033 – a potent, non-steroidal bodybuilding supplement for enhancing lean muscle mass and reducing body fat
  • Ostarine (MK-2866) – selective for anabolic activity at certain ARs, great for maintaining and increasing lean body mass and recomping
  • S4 (Andarine) – selective for bone tissue (mostly low virilization), aimed to cure osteoporosis and won’t produce the development of prostate and other secondary sexual organs
  • RAD140 – this is probably one of the most exciting SARMs, as well as the most current. In fact, aside from the muscle building effects seems to look like a possible cure for Alzheimer.

Other compounds like GW 501516 (Cardarine) considered the kind of endurance supplements and SR9009 are usually grouped with SARMs, but are not the same.

The Benefits of SARMS

SARMS is believed to have the capacity to employ the benefits of anabolic supplements while reducing the side effects of steroids.

  • Non-toxic (won’t cause liver damage)
  • Avoids bone loss (direct action of testosterone in bone thru the AR-mediated conduit is critical for its anabolic effects in bone)
  • Decreases the threat of prostate problems in men without muscle mass loss
  • Won’t impede your HPTA
  • Similar effects with testosterone
  • No estrogen and Dihydrotestosterone (a hydrogen hormone) conversion

For muscle builders, taking SARMS will give:

  • Muscle loss prevention (during cutting period)
  • Lean muscle development
  • Improved strength
  • Faster injury recovery
  • Joint healing abilities
  • PCT use following anabolics

Let’s a took at a few of these benefits in more detail…

Increased muscle strength

In the Asian Journal of Andrology, subjects increased muscle strength 20x more than those in the placebo group. Subjects continued to gain strength and size in muscle tissue for up to 5 months but with significant decreases in effectiveness after the 3rd month (Dalton et al, 2014).

Increased muscle size

Deductive evidence has proven a significant increase in muscle tissue hypertrophy (growth of muscle tissue). Inductive evidence suggests subjects will gain between 3 to 15 lbs of muscle tissue over the a 12 week period (Dubois et al, 2015). The amount of muscle hypertrophy is dependent on diet, training, and the characteristics of the SARM. Mild SARMs such as MK2866 will range much lower in hypertrophy than more potent SARMs such as RAD140 or LGD4033.

Tissue selectivity

According to the Oxford Academic journal of Endocrinology, nonsteroidal SARMs have been designed to attach itself to area of the DNA responsible for skeletal muscle protein synthesis. Unlike other anabolic agents, non steroidal SARMs do not affect any other tissues in the body (Dubois et al, 2015).

Inhibits cancer cell division

In an unrelated study to muscle growth performed by the Public Library of Science’s (PLOS) Peer Reviewed Open Access Journal, nonsteroidal SARMs have been studied for its effects on breast cancer. Androgen receptors are known to play a pivotal role in the treatment of breast cancer and due to the inability for nonsteroidal SARMs to convert to estrogen, there is a very narrow probability for negative repercussions. The results have not only confirmed that tumor cells decrease in weight by 90%, but it may even inhibit the potential for breast cancer development (Dalton et al, 2014).

Regulation of libido

Recent studies have indicated healthy increases in sexual desire in both men and women with the use of nonsteroidal SARMs. The males with hypogonadism, testosterone therapy is a common practice. In testosterone therapy there are many side effects that result is severe consequences for the user, such as thickening of the blood (commonly causing strokes and heart attacks), enlargement or development of cancer on the prostate, and gynecomastia (characterized as the development of female breast on men) due to an overproduction of estrogen. A 2014 article published by the Asian Journal of Andrology stated “SARM’s beneficial pharmacology and desirable pharmacokinetics offer considerable promise in the treatment of late onset hypogonadism. The convenience of once daily oral therapy combined with defined safety margins surrounding a proven efficacious dosage form may one day challenge testosterone replacement therapy as the gold standard in treating late onset hypogonadism” (Dalton et al, 2014).

In the Journal of Pharmacology and Experimental Therapeutics, Researcher reported positive effects of nonsteroidal SARMs on females with low sexual motivation indicating noticeable increases in sexual desire (Jones et al, 2010).

Safety and tolerability

In the Oxford Journal of Gerontology Series A: Biological Sciences and Medical Sciences, the popular nonsteroidal SARM LGD 4033 (Ligandrol) has been recently studied for it’s effectiveness and safety in healthy young men. Results were favorable indicated by hormone and lipid levels returning to normal without the use of a post cycle therapy. No dangers were detected throughout the study. although there was noticeable suppression in testosterone and HDL cholesterol, it was not significant enough to cause adverse reactions. Because LGD 4033 is considered one of the strongest and most potent nonsteroidal SARMs available, it is not likely that less potent SARMs will produce any harmful effects (Bhasin, 2010).

Side Effects of SARMS

What’s great about SARMS is that its side effects are minimal, so you don’t have to worry about any negative effects. If you overdo it, however, some people may experience shut down or even gynecomastia if currently predisposed to it.

Be responsible, and in 99.9% of cases users will not have any side effects from the use of SARMs. Current research has so far agreed with that conclusion.

Where to Buy Selective Androgen Receptor Modulators Online

There are many manufacturers selling SARMs online right now. Although they are not legal for human consumption, you can buy them from many research labs to experiment with your rat.

There are multiple companies selling SARMs online, and the only place I’ve been going to has been the company Innovative Research Chemicals. In fact, as of January 8th 2018 of this year, their popularity all over reddit and solid reputation caused them to upgrade to a bigger facility.

You can check out their homepage for a selection of SARMs and other useful compounds.

Stacking Your SARMs: Your Best Options

When it comes to SARMs, many people stack more than 1 at a time to maximize their results even further. Since in most cases you won’t experience any side effects using SARMs, you can safely stack multiple compounds and do a total recomp of your physique.

KONG is a 5 SARM compound available at Powersupps UK

For the best stack right now, I highly recommend you check out a product called KONG by Medfit Nutrition. This is a capsule containing 5 different SARMs in one. It’s probably the strongest SARM product we’ve seen online right now.

Popular stacks for SARMs include:

Liquid SARMs are harder to stack because of the pure taste and inconvenience of having to measure it out multiple times a day. Plus it tends to be much more expensive. That’s why capsules are your best bet for stacking, while liquids are best for taking one SARM at a time.

SARMs: Our Final Review

With SARMS showing great promise for selective high anabolic muscle activity and in preventing muscle wasting and age related illnesses without the negative side effects associated with anabolic steroids and prohormones, SARMS could be the next big thing. The IOC (International Olympic Committee) is even preparing for the use of SARMS with Olympic athletes. It’s Anabolics 3.0 and the “Universal Soldier Formula” of the future!

What are your thoughts on SARMS? Feel free to leave a comment below.

FAQs

No, you don’t need to have a post cycle therapy or PCT after using SARMS. It’s one of the biggest reasons why SARMS are gathering quite a loyal following these days. Since they don’t disrupt the hormonal levels in the body, you won’t be prone to the nasty side effects that anabolic steroid and prohormone cycles can trigger without a proper PCT program. All you need is some basic over the counter PCT supplements and you’re good to go.

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Miller, Chris P., Maysoun Shomali, C. Richard Lyttle, Louis St. L. O’Dea, Hillary Herendeen, Kyla Gallacher, Dottie Paquin, Dennis R. Compton, Bishwabhusan Sahoo, Sean A. Kerrigan, Matthew S. Burge, Michael Nickels, Jennifer L. Green, John A. Katzenellenbogen, Alexei Tchesnokov, and Gary Hattersley. “Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140.” ACS Medicinal Chemistry Letters. American Chemical Society, 10 Feb. 2011. Web. 22 Apr. 2017.

Dubois, Vanessa, Ioannis Simitsidellis, Michaël R. Laurent, Ferran Jardi, Philippa T. K. Saunders, Dirk Vanderschueren, and Frank Claessens. “Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage.” Endocrinology. Oxford University Press, 01 Dec. 2015. Web. 22 Apr. 2017.

Dubois, V., I. Simitsidellis, M. R. Laurent, F. Jardi, P. T. Saunders, D. Vanderschueren, and F. Claessens. “Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage.” Endocrinology. U.S. National Library of Medicine, Dec. 2015. Web. 22 Apr. 2017.

Basaria, Shehzad, Lauren Collins, E. Lichar Dillon, Katie Orwoll, Thomas W. Storer, Renee Miciek, Jagadish Ulloor, Anqi Zhang, Richard Eder, Heather Zientek, Gilad Gordon, Syed Kazmi, Melinda Sheffield-Moore, and Shalender Bhasin. “The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men.” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. Oxford University Press, Jan. 2013. Web. 22 Apr. 2017.

Mohler, M. L., C. E. Bohl, A. Jones, C. C. Coss, R. Narayanan, Y. He, D. J. Hwang, J. T. Dalton, and D. D. Miller. “Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.” Journal of medicinal chemistry. U.S. National Library of Medicine, 25 June 2009. Web. 22 Apr. 2017.

Coss, Christopher C., Amanda Jones, Michael L. Hancock, Mitchell S. Steiner, and James T. Dalton. “Selective androgen receptor modulators for the treatment of late onset male hypogonadism.” Asian Journal of Andrology. Medknow Publications & Media Pvt Ltd, 2014. Web. 22 Apr. 2017.

Dalton, J. T., R. P. Taylor, M. L. Mohler, and M. S. Steiner. “Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer.” Current opinion in supportive and palliative care. U.S. National Library of Medicine, Dec. 2013. Web. 22 Apr. 2017.

Narayanan, Ramesh, Sunjoo Ahn, Misty D. Cheney, Muralimohan Yepuru, Duane D. Miller, Mitchell S. Steiner, and James T. Dalton. “Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling.” PLoS ONE. Public Library of Science, 2014. Web. 22 Apr. 2017.

Jayaraman, Anusha et al. “Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats.” Endocrinology 155.4 (2014): 1398–1406. PMC. Web. 23 Apr. 2017.

17 Comments
  1. Mr .m says

    What can I take if my good cholesterol is low and I’m on a tren ,test cycle

    1. Dr adarsh says

      Take tab niacin(vitamin B6)1gm tds fr 6 wks if u dont have any bleeding tendency.

    2. James H says

      GW 501516 a.k.a. cardarine, it will also help with your respiratory system side effects from Tren and cholesterol issue and blood pressure.

  2. Stephanie Watts says

    Are there any studies (long-term or otherwise) on the effects of these products on women?

  3. Paul Gianni says

    I’m looking for a boost in general test (mine has been tested and is dreadfully low), not necessarily for body sculpting. Since I will not complain about lean gains , I would like to know which SARM would be best for a 48 year-old man who recently had a heart attack.

    Thank you,
    Paul

  4. Robert Johnson DC says

    Is there a minimum age that is recommended for an athlete to start considering using SARM’s ( ie : high school football players ) and if so , which do you recommemd ?

  5. Margaret Gillespie says

    Is sarm’s safe to take if you have ADHD Autism and on two different types of medication also does taking sarm’s increase the likelihood of increased aggression in these circumstances thanks

  6. melton woolboy says

    I need something to build muscle and get strong …so I find MK 2866 one of my friend told me to use it…he said it really works so im going try it

  7. David Norman says

    SARMS are great but my rat doesnt like the taste of the liquid kind. Any help with that?

    1. Sealey says

      Your rat? What does that mean?

    2. Nutrition says

      You should tell your rats to take it along with your shake ! (no in the shake but along with it !)

  8. Ben Brown says

    I have hypothyroidism so just wondering if there are any sarms that I should not take. Or stay away from, I’m just getting back into weight lifting again after several yrs. I’m looking for a sarm that I can get strong on and lose alittle on the sides. Any recommendations.

  9. Phoenix23 says

    Someone please respond to this. I’m looking to do the exact same. I want put on lean muscle. Strength and burn off stubborn belly fat.

  10. Gabe says

    Am I supposed to take sarms on my rest days as well?

  11. Keith says

    I am taking 40 mgs Lipatordaily, 200mg Test cyapinate weekly for muscle loss.
    What would you suggest as a sarms stack that is safe with the Lipator? Taking 40mgs Lipator daily. I need to make sure there is no muscle loss.
    I’m 60 years old and intermediate lifter, if that makes any difference.

  12. David says

    Is there any benefit in the shoulder joint as it’s damaged after an injury and the bones are painful

  13. DAVID says

    WHAT SARMS ARE SAFE FOR A TYPE 2 DIABETIC.I HAVE BEEN BODY BUILDING FOR 2 YEARS.IM 69 YEARS OLD AND HAVE MADE SOME GREAT STRIDES IN MUSCLE MASS BUT WOULD LIKE TO PUT ON A LITTLE MORE MUSCLE.ARMS 14 TO A 16 INCH CHEST 38 T0 42 WAIST 34 TO 30.

Comments are closed.