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YK11


Chemical Name: (17-alpha,20E) 17,20-[(1-methoxyethylidene)bis(oxy)] 3-oxo-19-norpregna-4,20-diene 21-carboxylic acid methyl ester
Other Name(s): YK11, Myostine
Molecular Name: C25H34O6
Half Life: 6-10 hours, depending on individual

YK11, also known as Myostine, is considered one of the strongest SARMs on the market. In fact, it’s so strong and has comparable anabolic activity to steroids that it may actually be a synthetic steroid that was mislabeled a SARM in the first place.

History

YK11 was first studied by Japanese researcher Yuichiro Kanno in 2011. It was found to be a partial agonist of the Androgen Receptor (AR) with gene-selective properties, leading researchers to suggest that the compound is a SARM. [1]

To date, limited studies have been undertaken, although preliminary findings in vitro on muscle cells are very promising. Initial studies suggest that YK11 may have greater muscle building effects than those of DHT and a propensity to act as a myostatin inhibitor.

How YK11 works

As a relatively new compound, exactly how YK11 works to improve lean muscle mass in humans can only be discussed based on initial in vitro studies.

However, what we do know is that YK11 may be a Myostatin blocker – essentially allowing users to reap continuous gains without stalling and requiring a break in a cycle.

Myostatin is a protein that is released to limit muscle growth to ensure they do not get ‘too large’. It is found predominantly in skeletal muscle, and studies show that individuals with a gene mutation that limits Myostatin production are both stronger and more muscular than those with normal amounts.

YK11 may help to inhibit the production of Myostatin in muscles by attaching itself to the Androgen Receptor. From there, it may induce muscles to create more Follistatin, which in turn limits the levels of Myostatin, allowing increased muscle growth beyond genetic capability.

The confusion over whether Myostatin is a SARM or a steroid lies in the naming conventions (or lack thereof) in relation to newer compounds. Kanno, the original Japanese researcher, discovered that YK11 works via the androgen receptor, which is why he initially claimed it to be a SARM.

Newer research suggests that the backbone of YK11 is identical to those of steroids. In reality, we won’t know for sure until more studies are conducted.

User review

I just started running YK11 three days ago, and so far this stuff has made me feel like a complete animal in the gym. It’s very good stuff…makes you very dense feeling and gives you a ton of energy in the gym.

– Gruntstyle2

Benefits of YK11

There are 3 primary benefits that have been observed in both initial studies and user-reported reviews.

  1. YK11 may block Myostatin, allowing continues lean body mass gains

The primary benefit of YK11 and the reason it shows huge promise in the bodybuilding world is its potential to activate more Follistatin in muscles, subsequently blocking the production of Myostatin. By blocking Myostatin, a user could potentially unleash huge gains with continuous muscle growth. [1]

  1. YK11 may be comparable to testosterone in its ability to build strength in muscles

It’s a commonly held belief that while SARMs produce less negative side effects than testosterone, they’re also less effective at creating an anabolic effect in muscle growth.

Initial studies [1] show that muscle cells produce more anabolic factors when exposed to YK11 than they do when exposed to DHT (testosterone). This suggests that YK11 is potentially more powerful than testosterone at producing impressive gains with fewer side effects than steroids.

  1. YK11 shows potential for fast, large gains

Many users report seeing results from YK11 in as little as a single week of use, with the amazing results after an eight-week cycle.

YK-11 Side Effects

YK11 has only been tested in vitro – meaning that it has been tested on cells in a petri dish rather than on live animals or humans – where it has shown great promise in building lean muscle mass. However, this also means that until animal or human trials are conducted, we will not know what the potential side effects may be.

Anecdotal evidence from individuals who have cycled YK11 suggests that for those prone to hair loss, shedding may occur. Other users have noted zero hair loss, so it may be a case-by-case situation based on each individual.

Other anecdotal evidence suggests that mild acne may be a side effect of YK11, but this also disappears after a few weeks or once the cycle is complete.

It has also been suggested that YK11 may cause mild, reversible liver damage. This means that any damage caused is repaired by the body once the cycle is complete. Make sure to purchase a cycle support product in order to help protect your liver and other organs.

If you do experience any serious side effects, make sure to stop taking YK11.

YK11 Dosing Recommendations

YK11 Dosage
Dosing Guidelines for YK11

User reviews suggest that the ideal human dosage for YK11 is 2-5mg twice per day for eight weeks (a total of 5-10mg per day for men). The dosage can be split up in 2 times a day, depending on what kind of substance you have. Sarms4you sells capsulated and powder YK11 so you can easily decide what kinda dosage you need. The capsules come in 5mg, that means you can take 1-2 caps a day.  1 in the morning and 1 in the evening.

Anecdotally, some users suggest increasing the YK11 dosage to 20mg per day in total over the course of a cycle, although it’s best to start at a lower dosage and find your sweet spot.

Men

5-10mg total per day split into two doses.

Women

0.5-2mg total per day split into two doses.

Stacking YK11 with other SARMs

There have been quite a few anecdotal reports from users who have stacked YK11 with RAD140 with incredible results.

YK11 is often stacked with LGD-4033. LGD-4033, also called Ligandrol, is known for its ability to gain a lot of lean muscle similar to RAD140.  A YK11  LGD stack would be great for gaining lean muscle mass in a short period of time

Users report increased strength and an increase in lean muscle mass similar to testosterone results but without the water bloat. It works great for users looking to bulk with lean, dry gains.

Dosages RAD140 YK11 stack:

  • RAD140 (Testolone) – 15-30mg
  • YK11 (Myostine) – 5-10mg

Dosages YK11 LGD stack:

  • LGD-4033 (Ligandrol) – 5-15mg
  • YK11 (Myostine) – 5-10mg

USER REVIEW

“I’m no Doctor or Scientist here, but I know what works. This stack (YK11 and RAD140) is absolutely killing it!! Shit, I may run it out 12 weeks instead of just 8 weeks. The gains just keep coming, I don’t want them to end anytime soon!!”

– John Doe

Where to Buy YK 11 Online

YK11 can be easily and legally purchased online for research purposes, which means there are ample companies to choose from. However, as the compound is yet to be approved for human consumption, the SARM industry is unregulated and it’s important to do your due diligence in finding a reputable supplier.

A recent ban has forced some reputable distributors to shut down. The best recommendation we can give is Sarms4you.com, which offers worldwide deliveries, including the US.

buy yk11

These guys offer top-notch SARMs. Sarms4You has the highest quality YK-11 available right now.  If you are looking for an alternative, the YK-11 by Medfit RX is a total winner. The lowest price and fastest shipping we found were at Powersupps UK.

Buy YK-11 Online at Powersupps UK

YK11 before and after

Below you can see an amazing before and after picture from a member of a bodybuilding community. This is a typical YK11 Before and After picture. The results speak for themselves. This stuff is known for increasing lean muscle mass VERY rapidly. This user also reported enormous strength gains from 10mg of YK11. The cycle itself took about 8 weeks in total.

YK11 Before and after
YK11 Before and after 8 weeks

Just look, this guy even lost a ton of bodyfat whilst gaining muscle mass. That is a very hard thing to do, but with the help of YK11 you can do so easily.  The reason that YK11 gives such crazy results is because its one of the strongest SARMs out there. I am pretty confident either RAD-140 or YK-11 is the most powerful SARM out there based on the results I have seen.

To achieve similar results as in the YK11 Before and after you will also need a good workout strategy. Heavy weight lifting in combination with a high protein diet will do wonders.  YK11 will put on mass as no other product will do, it is a very potent SARM. You can also expect good pumps and increased vascularity.

My recommendation would be to start out with a low dosage of YK11 to see how you react to the compound. I would definitely not exceed the recommended dosage of 10mg, because there might be potential side effects from there on. You can achieve great results by doing 5mg for roughly 8 weeks, so there is no real reason to do a crazy high dose.

YK11 Final Review

Although YK11 has not been officially clinically trialled or studied on humans or animals, the anecdotal evidence from real users is hugely compelling. Many users note feeling stronger, more muscular and with better pumps and dry bulk even comparable to testosterone.

Additionally, users have reported minimal or mild side effects compared to the benefits gained. They also report faster gains than usual, with most stating that they noticed changes in their bodies within a week of use.

However, as with all SARMs (and especially with compounds that have not been subjected to rigorous animal and clinical trials), anecdotal evidence should be taken with a grain of salt. Until human trials have been undertaken, there is no way to know exactly what YK11 can do to the majority of people or if it is safe long term.

Overall, YK11 shows great potential to create huge gains outside of genetic capability, and existing user reviews are very promising. But, more studies are needed to understand the efficacy and long-term effects of this compound.

USER REVIEW:

Pumps are still as good as when they really kicked in last week. Must have been 5 guys in the last 2 days asking me what the hell I’m taking, so it must be working. Legs are really feeling out, calves to. Wife told me today my calves look bigger and she never says anything unless it noticable.”

– Humpnpump

 

FAQs

To date, there have not been any clinical human or animal trials and YK11 is not FDA approved for human use. However, existing studies and user-reported reviews are promising, and side effects look to be minimal.

Anecdotally, some users report noticing changes in their physiques in as little as one week. However, for best results, an 8-week cycle is recommended.

Most user-reported reviews suggest taking YK11 for 8 weeks before taking a miniPCT of 4 weeks.

As YK11 does not appear to remarkably affect testosterone levels, it should be safe for women.

The suggested dosage of YK11 is 10-20mg per day, split into two doses. We suggest trialing different doses to find your sweet spot by starting at the lower dose before ramping up.

Yes. As it is mildly hepatotoxic (damaging to the liver), we strongly suggest taking a miniPCT for 4 weeks to ensure hormone levels are back to normal after an 8-12 week SARM cycle.

Most users report taking their dose of YK11 in a split dose, 10-hours apart.

Yes, YK11 is legal to purchase from a number of research companies for research purposes. It is not yet sold for human consumption.

There is some disagreement over whether YK11 is a SARM or a steroid. The original researcher suggests that it is a SARM. Others online suggest that the molecular structure mirrors that of a steroid. Until further research is done, a conclusive answer cannot be provided.

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References

[1] Kanno, Yuichiro et al. “Selective Androgen Receptor Modulator, YK11, Regulates Myogenic Differentiation of C2C12 Myoblasts by Follistatin Expression.” Biological and Pharmaceutical Bulletin Volume 36 (2013) Issue 9 Pages 1460-1465 Web. 29 May. 2018.

https://www.jstage.jst.go.jp/article/bpb/36/9/36_b13-00231/_article

15 Comments
  1. Steve Watkins says

    hello, my name is steve watkins. I am an american that has now lived for 10 years in Mexico. I import a variety of supplements and sell them to Doctors and personal trainers here.

    I am certain that your yk11 Sarm will be a big hit here.

    I would like to see if you have any wholesale pricing available. I can see a pretty good business here if I can get a solid price point for these guys here.

    I hope to hear back from you,

    Steve

    1. Bert Stare says

      Aaaaand he was never heard from again haha

  2. brad says

    Where is a good place to get yk11?

  3. Gurpreet singh says

    Hi
    I m was going to start my tren acetate/ test cycle/ GW 50516 / OSTA cycle for 10weeks , I dnt know much bout YK11 , shud this be good adding to the cycle or in PCT???

  4. Bill Reedy says

    I just bought YK11 chem-tek-labs capsules, do I take on an empty stomach or does that matter, and if I take 1 at 7a.m. when or how often do I take the other 2, they are not clear on this? My doc. has me on 200mg/wk cypionate will this go well with the YK11???? Thanks Bill

    1. paul says

      you cant ask questions about taking these sarms for yourself because they are not for human consumption and these places would get in toruble. You have to say something like “I have a lab rat that is going to start taking lgd4033 how long should he be on it”

  5. nuno says

    i would like to know more feedbacks from users of yk 11 .results , sides, what to expect from a yk11 cycle.. Anyone ??

  6. Bob Larkins says

    I was just reading about YK11. Where can this be bought at and what is the price?

  7. Bob Larkins says

    where can YK11 be purchased

  8. Linda says

    I am 56 female..can I take this YK11? I want more size and muscle as an competitor.

  9. Linda says

    What products do you have that i can try that will help my physique as an female..any samples?

  10. CHEW says

    I had this once. Such a great product. Feel so much stronger. Muscle mass just comes. Especially with the diet. This stuff seriously makes more muscle than a cycle. I just can’t get my hands on more. Hard to find

  11. russell carney jr says

    Why are they so hard to come by and expensive in these early stages, usually there promoting this at a low price to get it out there. I’ve been trying to buy bulk with testing kits and info. Nobody wants to help?

  12. Mustang says

    Yk-11 is not a SARM it’s a synthetic steroid. Do your research people. No Animal or Human trails have ever been conducted. 0 information on this Chemical. All studies have been in test tubes. No one knows the dosage or the effects. Stay safe my friends

  13. Felix minnow says

    My rat has taken this supplement and he has gotten great results!!👍no joke this stuff really works .way better than a cycle which he loses almost all his gain.but the side effects!he has taken various steroids and he has limp d1@k..,,poor Felix

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