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RAD140 (Testolone)

Chemical Name: 2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile
Other Name(s): RAD 140, Testolone
Molecular Name: C20H16ClN5O2
Half Life: 12-18 hours depending on individual

RAD 140, also known as Testolone, is an orally bioavailable, non-steroidal, selective androgen receptor modulator (SARM) that has the ability to increase lean muscle mass and reinforce the effects of testosterone without the unwanted side effects of anabolic steroids.

Early studies and user reviews have delivered better results than steroid use with minimal side effects, making it one of the most exciting and powerful SARMs to date. Read on for a comprehensive review of everything you need to know about RAD 140, including benefits, side effects, studies and results for increasing muscle mass and preserving gains.

History of RAD 140

RAD140 is currently being developed by the pharmaceutical company Radius. Its initial discovery was originally published in 2010, which means studies are limited. However, initial studies, company reports, and anecdotal user reviews have been highly promising for building muscle without the side effects of anabolic steroids.

Discovered via an Internal Discovery Program, Testolone is actually being developed for the treatment of breast cancer and muscle wasting in postmenopausal women. According to the company’s website, the FDA accepted their Investigational New Drug Application and the first human clinical trial was expected to begin in 2017.

How RAD140 Works

The androgen receptor (AR) primarily targets normal human sexual development, but its activation by compounds (such as testosterone) also affects bone, muscle, liver and the central nervous system.

The problem within the medical and bodybuilding communities is that using testosterone to activate AR signaling for increased muscle and bone development also affects the sex tissues, resulting in testicular atrophy, enlarged clitoris in females and even risks of prostate cancer. [1]

RAD140, a nonsteroidal selective androgen receptor modulator (SARM) bypasses this issue. Due to the way RAD140 binds to the androgen receptor, different cells respond by releasing different proteins, with only some androgen receptors being activated throughout the body.

This stimulation results in androgen receptor activation in bone and muscle cell, rather than raising liver enzymes or affecting sexual tissue.

According to the Cambridge-based pharmaceuticals company Radius:

“…The potent, orally bioavailable and nonsteroidal RAD 140 is designed to make the hormonal receptors in the tissues of the body act as if they’re getting a good dose of testosterone, setting off the same effects of prohormones and anabolic steroids minus the unwanted side effects…”

Benefits of RAD140

There are 8 primary benefits that have been observed in both initial studies and user-reported reviews.

RAD 140 - User's Review
User Review

1. RAD140 helps increase muscle mass

The number one benefit of supplementing with RAD140 is its ability to increase lean tissue without increasing fat. In fact, during initial studies done on monkeys, scientists observed an average weight gain of more than 10% in just 28 days. This was done using only RAD 140 and without any adverse side effects traditionally related to testosterone.

2. RAD140 may enhance speed, stamina, and endurance during high-intensity workouts

Want to work out longer, harder and get better results every time you hit the gym? Reports of enhanced speed, stamina, and endurance during workouts are common when supplementing with Testolone. Additionally, thanks to its ability to increase lean muscle tissue and decrease fat, high-intensity workouts and interval training can be optimized every time.

3. RAD140 has a greater anabolic effect than testosterone

Similar to other SARMs such as LGD4033 (Ligandrol) or S4 (Andarine), RAD140 produces similar results to testosterone but without the side effects.

RAD140 interacts with the hormonal receptors of muscle and bone tissue in the same ways as larger doses of testosterone, all without the estrogenic side effects caused by anabolic steroids.

Many users on forums also report greater anabolic effects than testosterone and are sometimes used as a PCT for steroid users to retain muscle mass between cycles.

4. RAD140 may reduce the side effects of testosterone

When taken in conjunction with anabolic steroids, initial studies indicated that RAD140 reduces the side effects of testosterone stimulation on the prostate and seminal vesicles of monkeys [2].

Additionally, many anabolic steroid users report concerns for the health of their liver. However, during the 28-day trial, these monkeys also showed minimal liver enzyme elevations on a dose 10x higher than the fully effective dose, even though a weight was gained during a short timeframe (which can cause liver strain).

Our advice?

With the results from RAD140 already proving better than anabolic steroid use, users may be better off forgetting testosterone altogether and sticking to SARMs.

5. Testolone does not appear to have the same side effects of anabolic steroids on reproductive organs

Initial studies on mice have found that low doses of RAD140 are all that’s needed to stimulate muscle growth without affecting the weight of the prostate.

This means that RAD140 has the ability to selectively stimulate muscle and bone growth while reducing the effects on sex tissue such as the prostate or clitoris. (So yes, this means RAD140 is safe for women)

6. RAD140 may aid weight loss by increasing fat loss

RAD140 indirectly reduces body fat by increasing muscle and bone cells, which are more metabolically expensive to maintain than fat cells. By increasing muscle mass, an increase in the metabolism is seen, which results in easier weight loss [3].

Users also report increased muscle growth and decreased fat stores thanks to RAD140’s ability to increase stamina, endurance, and speed during an interval training.

7. RAD140 is being trialed for the treatment of breast cancer

RAD140 was discovered and is currently being developed by pharmaceutical company Radius specifically for the treatment of Androgen Receptor (AR) and Estrogen Receptor Positive (ER+) breast cancer in postmenopausal women.

In vitro studies completed in 2017 showed that RAD140 inhibited the growth of AR/ER+ breast cancer cells. Results from these studies supported further investigation of RAD140 as a breast cancer treatment, and the first human clinical trials were brought forward [4].

8. RAD140 is indicated to be neuroprotective for brain health in neurodegenerative diseases

As testosterone levels in men decline, the risk of disease in androgen-responsive tissue (including the brain) increases, implicating the development of neurodegenerative diseases such as Alzheimer’s Disease.

However, treating AR diseases with testosterone may increase the risk of prostate cancer. Recent studies suggest that RAD140 may be as effective as testosterone in reducing cell death without side effects to the prostate. [5]

RAD140 Side Effects

As with most SARMs, studies show that RAD140 does not appear to have any side effects common to steroidal compounds. Unlike testosterone, RAD140 does not cause prostate enlargement or testicular shrinkage.

However, as it is still in early developmental stages, this does not mean that there are no long-term effects. Some user-reported side effects include headaches or insomnia that disappear with correct dosage.

RAD140 Dosage Guideline

Testolone studies are still being produced, but it has been known to have equal potency and effectiveness to that of LGD4033.

Studies on male primates suggest 20-30mg per day every 24-36 hours is optimal for maximum skeletal hypertrophy, in line with anecdotal testimonials from users. Safe durations for research have been tolerated for up to 12 weeks, however, developing trials may indicate a tolerance for up to 24 weeks.

It is important to note that RAD140 systematically regulates the neuroexcitatory amino acid Kainate which activates glutamate receptors in the brain. Kainate acid’s role in neuronal cell death (specifically in the hippocampus) has been shown to be a primary contributor to Alzheimer’s disease. RAD140 has demonstrated positive results in the prevention of Kainate acid production and medical based research published by The Endocrine Society suggests RAD140 can improve brain health through neuroprotective properties in as little as 13 days (Jayaraman, 2014).

Although safe for women, lower doses ARE recommended. Females are advised to start at 5mg per day with an upper limit of no more than 10mg per day.

RAD 140 Dosage Table

Although there is no official human dose for RAD140, its potency and effectiveness have been compared to LGD4033.

Current research indicates that it is tolerated for use up to 12 weeks. We suggest that you do not exceed these 12 weeks in order to get the best results.

Rad140 Vs Ostarine

Ostarine is the most popular and successful product of SARM up till now. It is used for a wide range of fitness goals. Many athletes add Ostarine in their diet to improve their athletic performance and enhance their muscular look.

This compound is known for its amazing cutting abilities. It shreds your body fat super fast and leaves you with lean muscle mass. Its results are quite similar to those of anabolic steroids but without the side effects that come with them. This means that you don’t need to worry about damaging your liver or heart health. Also, it does not lead to issues like high blood pressure, gynecomastia, hair loss, acne, mood swings, and libido issues.

RAD 140 works quite similarly to Ostarine when it comes to fitness goals. It not only helps build lean muscle mass but also boosts strength levels significantly. Moreover, it is a great tool for cutting purposes and builds stamina. It can also be used to improve athletic performance.

However, this compound is slightly potent for the beginners so it is recommended that they should go for Ostarine first before trying RAD 140.

If your fitness goals include bulking then RAD 140 is definitely a better option because it is more powerful than Ostarine in this case. You can expect to gain significant lean muscle mass within 8 to 12 weeks of cycle. However, results will vary across individuals but everybody will see considerable increases in their lean muscle mass with RAD 140.

This compound lacks androgenic effects which is a good thing because you don’t need to worry about issues like gynecomastia, hair loss, acne, liver toxicity, and high blood pressure etc.

The cutting results for RAD 140 and Ostarine are quite similar. However, RAD 140 does a better job when it comes to maintaining stubborn muscles and strength levels during the cutting phase. This is basically due to the high anabolic ratio of this compound.


Although great on its own, RAD140 can be stacked with other SARMs for added benefits tailored to your individual needs.

Many users report stacking RAD140 (Testolone) with MK677 (Nutrobal) and MK2866 (Ostarine) to provide a powerhouse for building muscle, burning fat, boosting growth hormones, joint recovery and improved sleep.

Testolone is particularly beneficial for older users who benefit from reduced muscle wastage, joint health and better sleep for recovery.


  • RAD140 (Testolone) – 30mg
  • MK2866 (Ostarine) – 25mg
  • MK677 (Nutrabol) – 12mg

Looking for the ultimate SARM stack? KONG provides a well-rounded selection of SARMs chosen to work synergistically.

Take the hassle (and cost) out of purchasing your SARMs separately –

KONG is a 5 SARM stack that contains 6mg of RAD140, as well as GW 501516, MK 2866, MK 677, and LGD 4033.

Where You Can Buy RAD140 (Testolone) Online

Buy RAD140 (Testolone) OnlineRAD140 can be easily and legally purchased online for research purposes, which means there are ample companies to choose from. However, as the compound is yet to be approved for human consumption, the SARM industry is unregulated and it’s important to do your due diligence in finding a reputable supplier.

In fact, a recent study suggests that 52% of SARMS purchase online were incorrectly labeled and did not contain the correct ingredients.

A recent ban on SARM products has forced almost all the reputable distributors to shut down. however, if you are looking for genuine, high-quality products, is the best place to shop. We’ve found their RAD140 to be more affordable, and their customer service is excellent.

60 capsules are currently sold at $69.95 at

At the upper dosage limit, one bottle will last 10 days, which means at least 3-4 bottles will be required for a 4-week cycle. Lucky for you, Sarms4you offers greater discounts when you buy in bulk.

Note: They are currently dealing with low stock due to supply chain issues, so get it while you can.

An ideal SARM for women, RAD140 helps increase muscle mass and fat loss in women too. The best compound we’ve found for female athletes and bodybuilders is Athena.

ATHENA Women's Compound

It’s the ideal stack that includes RAD140 (Testolone), LGD4033 (Ligandrol) and MK2866 (Ostarine) for optimum results.

You can buy it online at Powersupps UK w/ free worldwide shipping.

Final Review

From the compelling research provided by the latest scientific studies to anecdotal user reviews of exceptional muscle gain with minimal side effects, it’s hard to fault RAD140 as a vital supplement in your bodybuilding toolkit.

Compared to other SARMs, RAD140 has been reported to deliver results in as little as 4 weeks, although longer cycles of up to 12 weeks are advised for the best results. Some user testimonials suggest amazing results after only a 6-week cycle.

Because it selectively targets muscle and bone tissue, RAD140 doesn’t have the side effects caused by steroid use. This lack of side effects and minimal testosterone release makes RAD140 ideal for both men and women looking for defined lean muscle and increased fat loss.

The only obvious concern with RAD140 is the limited clinical human studies that have been performed in the scientific community. However, studies on nonhuman primates look promising and are consistent with anecdotal testimonials from the bodybuilding communities.

If you’re looking for increased endurance, stamina, fat loss and muscle gains without the side effects of testosterone, RAD140 is a great choice for your next cycle.

Just finished my first RAD140 cycle. I had amazing results. Sadly my careless self spilled the bottle twice so my cycle was only 6 weeks but I’m definitely going to try it again and see the full potential.

– Cacoora2


Because RAD140 does not affect hormone levels, a full PCT is not necessary. However, many users strongly suggest taking a miniPCT for 4 weeks to ensure their hormone levels are back to normal after an 8-12 week SARM cycle.

Clinical trials are still being performed, and RAD140 is not FDA approved for human use. However, existing studies and user-reported reviews are promising, and side effects look to be minimal.

Initial studies showed results within a 28-day trial period on monkeys. Many users report muscle mass results after 4 weeks, although individual results may vary.

Most user-reported reviews suggest taking RAD140 for 8-12 weeks before taking a miniPCT of 4 weeks.

Yes! Along with other SARMs, RAD140 is safe for women to gain anabolic effects and build muscle without the masculinizing side effects of steroid use.

The suggested dosage is 20-30mg per day, although trialing different doses to find your sweet spot is recommended.

Most users report taking their dose of RAD140 in the morning or pre-workout, or that it doesn’t matter – it’s entirely up to each individual user.

Yes, RAD140 is legal to purchase from a number of research companies for research purposes. It is not yet sold for human consumption.

No, RAD140 is not a steroid and will not affect sexual tissue in the same way that anabolic steroids, such as testosterone, do. RAD140 is a SARM, which means it selectively targets muscle and bone cells instead of the prostate.

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Miller, Chris P. et al. “Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140.” ACS Medicinal Chemistry Letters 2.2 (2011): 124–129. PMC. Web. 2 Feb. 2018.

McPherron, Alexandra C. et al. “Increasing Muscle Mass to Improve Metabolism.” Adipocyte 2.2 (2013): 92–98. PMC. Web. 2 Feb. 2018.

Yu, Z et al. “Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action.” Clin Cancer Res 2017 Dec 15;23(24):7608-7620. Web. 2 Feb. 2018.

Javaraman, A et al. “Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats.” Endocrinology (2014) Apr;155(4):1398-406. Web. 2 Feb. 2018.

Wogoner RM, Van et al. “Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet.” JAMA (2017) Nov 28;318(20):2004-2010. Web. 2 Feb. 2018.

  1. Paul says

    I guess a dosage of 20mgs is too much for my rat because it made him sick for 2 days, with a headache, racing thoughts with sleeplessness. I recommend a very low dose to start. im actually scared to give it to him again so im holding off.

  2. Ericka says

    RAD-140 is for women too
    And how long Is good to take

  3. joe says

    can this be combined with mk-677 sarm say 0.5 ml of each orally together? and what do you need to take when you finish with it is there a pct needed and what is recommended?

  4. Tim says

    I’m taking 30 mg a day, it’s my 3rd in feel

    1. kenneth Whitfield says

      how do you take it

  5. Erica says

    Is sarms rad 140 capsules okay to take for women?

  6. Tony says

    My rat ran 20mg for 8 weeks with not too bad results..
    Very minimal shut-down if any.
    Second run, 1 week in on 25mg a day and I think this is the sweet spot for my rat rat ratty…he is instantly stronger and his female rat friend is liking)

  7. Jay leblanc says

    When do u take rad 140 and mk2866 before or after your workout for best results ???

  8. Aaron says

    I take 30mg a day. Have been taking it for 6 weeks and is by far my favorite sarm. It took a few weeks to really notice much physical/appearance changes but it’s really enabled me to morph my body. I’ve targeted my delts and quads during this cycle and have seen insane growth in those areas. Very happy with this product, gives me great pumps in the gym and has given me a much fuller and leaner look. Have not had any sides but will run a pct when done.

  9. Abwit.aliklik says

    For best results before or after workout ?

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